Imagine a world without pain; imagine a world with no ailments. Sounds amazing, right? Well, it is a fantasy too good to be true. The world today has become so full of stress and work demands that people are not able to manage the time for a few hours for themselves. You come back home and hold your neck that is almost stiff with pain. Resting is a slow healing process, and the pain will only recur again tomorrow. Pains like these needs a medication drug that has an immediate action benefit and that can last for a long time.
Mechanism of action
Now back to the working of Tramadol. When these mu receptors are acted on, they don’t “process” this expression of pain as well as they should, resulting in a decreased sensation of pain.
Tramadol also inhibits Norepinephrine reuptake, making more Norepinephrine available for your body’s disposal. This helps in easing the pain in a considerably low amount of time
Tramadol vs. other pain relief drugs
Tramadol, Morphine, Codeine are all well known pain relief medications. There have been studies showing side effects for all pain drugs when used for a long time continuously. It’s just a question of the one that has lesser number of side effects. Lets us have a comparative study between these three drugs.
Tramadol vs. Codeine
Codeine provides more effective pain improvement, and better tolerability compared to Tramadol. However as compared to Codeine, Tramadol has been known to have fewer side effects and most of them are short term side effects. Codeine is known to make a person drowsy soon after. Tramadol, though more potent than Codeine has far less serious side effects and the side effects wear off soon enough.
Tramadol vs. Morphine
Tramadol and Morphine are used in post-operative conditions. Tramadol however significantly shows lesser respiratory depression than Morphine. Also Tramadol does not induce Histamine release that can result in flushing, reddening or itching of the skin. At proper doses, Tramadol has no effect on heartbeat, left ventricular function.
Different studies have shown:
- Tramadol may represent a superior choice over morphine for children undergoing adenotonsillectomy, because of its potential to cause less postoperative sedation and respiratory depression
- Tramadol is as effective as morphine for moderate postoperative pain but it is less effective for severe acute pain
- Tramadol has been compared with morphine in patients with post-traumatic musculoskeletal pain in the pre-hospital setting. Intravenous Tramadol 100 mg was equivalent to morphine 5-10 mg, with similar incidence of side effects and similar degree of patient satisfaction
- Tramadol has the least osteoporotic effect as compared to morphine
- Tramadol has smaller inhibitory effect on gastric emptying compared with morphine.
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